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Many people experience recurrent redness, stinging, and a feeling of irritation after using recombinant collagen products. The root cause is often not the collagen itself, but residual endotoxins (...

1. Installation Install the hollow fiber module and connect all tubing. Place the feed tubing into purified water, and place both the retentate tubing and permeate tubing into a waste container. 2....

What should be done if the design space established during process characterization is either broader or narrower than the operating parameter ranges used for manufacturing Phase III clinical trial...

We purchased membrane cassettes with the same MWCO from two different manufacturers. During diafiltration experiments, we observed a significant difference in product recovery. Further analysis sho...

Tangential Flow Filtration (TFF) is widely used in both biopharmaceutical and chemical pharmaceutical processing as a key technology for buffer exchange and purification. Among all process componen...

Solid-phase peptide synthesis (SPPS) is a method for synthesizing peptides on a solid support. The main SPPS strategies include the Boc method and the Fmoc method . Peptide synthesis is a repetitiv...

Peptide therapeutics, due to their strong targeting ability and high safety profile, have become key treatment options for diseases such as diabetes and cancer. However, the complex impurities gene...

During peptide purification, a series of typical issues may arise, which can stem from sample pretreatment, mobile phase selection, chromatography resin choice, and purification condition settings....

Bovine infectious rhinotracheitis (IBR) is caused by infection with the bovine infectious rhinotracheitis virus (IBRV), also known as bovine herpesvirus type 1 (BHV-1). The disease is mainly charac...

In recent years, mRNA technology has achieved breakthrough progress in the biopharmaceutical field, demonstrating tremendous application potential, particularly in vaccines and gene therapy. The su...

As a key separation and purification technology in biopharmaceutical processes, Tangential Flow Filtration (TFF) leverages its unique separation mechanism-where the liquid flows tangentially across...

Bacteriophages, also known as phages, are viruses that infect bacteria. A phage cannot survive on its own; it must parasitize a host bacterium to reproduce, ultimately causing the bacterium to lyse...