membrane cassettes

Your Professional Membrane Cassettes Supplier

Hangzhou Guidling Technology Co., Ltd. is an innovative manufacturer established in 2015, specializing in downstream biopharmaceutical purification and separation solutions. We focus on clarification, concentration, and filtration processes for biological production. Our main products include ultrafiltration & microfiltration cassettes, TFF systems, centrifugal filter devices, depth filter modules, and virus removal filters. These products are widely used in antibodies, vaccines, diagnostics, blood products, and cell culture applications.

Stable Manufacturing Capability
We have a complete production system for filtration products, ensuring consistent quality and stable supply. Our manufacturing process is designed to meet industrial biopharmaceutical standards.

Continuous Product Development
We keep improving our filtration technologies and have developed multiple product series since 2015. This allows us to provide updated and efficient solutions for downstream purification needs.

Flexible Application Solutions
Our products are designed for different bioprocess stages, including clarification, concentration, and virus removal. This helps customers build more efficient and customized filtration workflows.

Reliable Cooperation Support
We focus on long-term cooperation with customers by providing responsive communication and technical assistance. Our aim is to support smooth project operation from selection to application.

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High performance membrane cassettes for biopharmaceutical process development, scale-up and scale-down, concentration, purification, and cell harvesting applications.

Parameter

Membrane pore	1/3/5/8/10/30/50/100/300/500/1000kd/0.22μm/0.45μm
Max inlet pressure	≤4.2bar
TMP	4.5bar（80psi）at 4-45℃
Working temperature range	4-45℃
pH	1-14
Flux measurement	100% flux test before delivery
Integrity test	100% integrity test before delivery

Types of Membrane Cassettes

The membrane cassettes produced by our company mainly include the following types:

Ultrafiltration Cassettes
Ultrafiltration cassettes are specialized flat-sheet filters used in Tangential Flow Filtration (TFF) systems. They operate by repeatedly passing a fluid parallel across a membrane surface.

Microfiltration Cassettes
Microfiltration cassettes are specialized membrane filtration devices used in biopharma, biotech, and laboratory settings. They rely on Tangential Flow Filtration (TFF) to separate or clarify liquids containing suspended particles, cells, and cell debris without clogging the filter.

Advantages of Membrane Cassettes

High Filtration Efficiency & Flux
The stacked flat-sheet design and built-in screen meshes generate turbulent flow across the membrane. This turbulence prevents material from settling, maximizing mass transfer and ensuring high flux rates.

Reduced Fouling & Concentration Polarization
Because the feed stream flows parallel (tangentially) to the membrane, particles and larger molecules are continuously swept away. This cross-flow mechanism significantly mitigates clogging and extends the lifespan of the filter.

Easy Scalability
Cassettes offer seamless scale-up from R&D to manufacturing. Surface area is increased simply by adding more membrane layers to the cassette or utilizing larger hardware holders, all while maintaining the exact same materials and channel geometries.

Gentle on Biomolecules
The fluid dynamics in cassette systems provide a controlled, low-shear environment, which is vital for maintaining the structural integrity of fragile proteins, vaccines, and viral vectors.

Compact Footprint
Compared to traditional settling tanks (in wastewater applications) or vast filter housings, cassette systems pack a large effective filtration area into a small physical footprint.

Applications of Membrane Cassettes

01/

Biopharmaceutical Industry
In the production of therapeutic proteins, monoclonal antibodies, and vaccines, Membrane cassettes are employed for protein concentration, buffer exchange, and virus removal.

02/

Cell Culture and Harvesting
Membrane is used to concentrate cell cultures and harvest proteins or cells from culture media in processes like cell therapy or gene therapy manufacturing.

03/

Water Purification
In laboratory settings and some industrial processes, Membrane cassettes are used for water filtration to remove contaminants, bacteria, and particles.

04/

Food and Beverage Processing
Membrane Cassettes is utilized in dairy processing, such as the concentration of milk or whey protein.

Key Conditions for the Long-Term Operation of Membrane Cassettes

To maintain good hydraulic circulation conditions in the bioreactor and possess an excellent hydraulic scouring effect on the membrane surface, the aeration rate should be appropriately increased.
Do a good job in the start-up operation of the reactor, which can increase the concentration of the inoculated sludge, and then start the operation of the membrane separation after the operation of the bioreactor is stable.
Pay attention to the daily maintenance of the membrane. We can adopt simple methods such as air aeration and online chemical cleaning to slow down the growth rate of membrane filtration resistance and prolong the membrane running time.
Maintain stable operating conditions. Frequent changes in operating conditions can promote membrane plugging processes and accelerate membrane fouling.
When using the MBR system, we should pay special attention to the pretreatment of sewage. Before the sewage enters the MBR, a grille below 2mm should be installed. For kitchen drainage with more grease, we should also install high-efficiency oil separation facilities. It is forbidden to directly enter the MBR system with the integrated domestic sewage that has not been treated by the septic tank.

Ordering Process

Send us your order list (models/quantities)
We will send you PROFORMA INVOICE (PI) with shipping cost and Payment information for your confirmation.
We will arrange delivery after your payment arrived and goods ready, and at the same time we will tell you goods tracking number so that you could know your goods condition by this number from courier site.

Packaging and Shipping

Packaging

Inner Packaging: Sterile protective bag or shrink wrap

Outer Packaging: Extra-thick cardboard carton

Shipping

For small quantity or sample will be shipped by DHL, FEDEX ,TNT ( shipping days 3-4 days).

For bigger quantity will be shipped by sea shipment to your pointed nearest seaport ( shipping days 1 month).

Our Factory

Our factory is located in the Hangzhou City, we have 5 production lines, which can produce 8000pcs cassettes and 5000pcs holders, and have about 100 workers in the factory.

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FAQ

Q: What are membrane cassettes?

A: Membrane cassettes are filtration devices used in bioprocessing to separate, concentrate, and purify biological solutions. They contain a membrane layer that allows selective filtration of molecules. Membrane cassettes are widely used in biopharmaceutical production for clarification and purification processes. They help improve product quality and efficiency while maintaining stable performance in laboratory and industrial applications.

Q: How do membrane cassettes work?

A: Membrane cassettes work by using pressure-driven filtration. Liquid flows across the membrane surface, and small molecules pass through while larger particles are retained. Membrane cassettes help separate impurities from target products. This process is commonly used in ultrafiltration and diafiltration systems for efficient biological purification.

Q: What materials are used in membrane cassettes?

A: Membrane cassettes are made from high-quality materials such as PESU or regenerated cellulose membranes. Support layers often use polyester or polypropylene. Membrane cassettes are designed to ensure low protein binding, high durability, and stable filtration performance in demanding bioprocess environments.

Q: What is the temperature range for membrane cassettes?

A: Membrane cassettes usually operate within a temperature range of 4°C to 45°C. This range ensures stable membrane performance while protecting biological samples. Membrane cassettes are designed to work safely under standard bioprocess conditions.

Q: How are membrane cassettes cleaned?

A: Membrane cassettes can be cleaned using standard cleaning-in-place (CIP) procedures. Cleaning solutions remove protein buildup and other residues. Proper cleaning extends the lifespan of membrane cassettes and maintains consistent filtration efficiency.

We're well-known as one of the leading filter cassettes manufacturers and suppliers in China. If you're going to wholesale bulk high quality filter cassettes in stock, welcome to get free sample from our factory.