Selection Of Ultrafiltration Membrane Package in Tangential Flow Filtration

The choice of ultrafiltration membrane materials has been perplexing most researchers, especially those who have just come into contact with TFF. The selection of appropriate membrane is the basis of tangential flow experiment.

Ultrafiltration membrane plays a filtering role in the very dense cortical structure. Usually, it is difficult for small molecules to enter the filter membrane. Therefore, ultrafiltration membrane is usually a pollutant accumulated on the surface of the membrane. Therefore, it is necessary to control the flow rate when operating ultrafiltration. To flush the surface of the filter membrane, optimize the pressure to adjust the filtration speed.

What kind of membrane is the ideal ultrafiltration membrane? It can be seen from the electron microscope pictures that the film coating layer is thin and the inner diameter of the support layer is large, so as to ensure rapid filtration, high flow rate and high flow rate. Basics. At the same time, it brings the possibility of elasticity. For molecules that need high flow rate, the flow rate can be increased, while for molecules that do not need high flow rate, the flow rate can be appropriately reduced.

The large pore size of the support layer allows to appropriately reduce the working pressure and reduce the damage to active molecules, so as to promote the purification and concentration of active biomolecules.

From the perspective of repeated cleaning, the support layer has a large pore diameter and can be thoroughly cleaned at an appropriate temperature. At the same time, good cleaning effect and high recovery rate can be achieved. If the pore diameter of the support layer is small, the cleaning temperature needs to be increased. At the same time, the possibility of cleaning failure is high, which means that the risk of pollution is greatly increased, and the recovery rate cannot be guaranteed at this time.