How To Choose Hollow Fiber Or Flat Cassettes In Tangential Flow Filtration Technology
Tangential flow filtration (TFF) technology is widely used in the biopharmaceutical industry for the purification and concentration of biomolecules such as proteins, antibodies, and vaccines. One of the key decisions in TFF is the selection of the appropriate filtration cassette, with hollow fiber and flat sheet cassettes being the two main options. Both types of cassettes have their own advantages and limitations, and the choice between them depends on the specific requirements of the application. In this article, we will discuss the factors to consider when choosing between hollow fiber and flat cassettes in TFF technology.
Hollow Fiber
Hollow fiber, a groundbreaking filtration technology, has revolutionized separation and purification processes across various industries. Hollow fiber features a robust membrane produced entirely in-house. With its gentle processing of shear-sensitive molecules during separation and its ability to handle high biomass and cell densities, hollow fiber enhances recovery and efficiency significantly.
Advantages
(1)Open flow channel, high dust holding capacity
(2)Good membrane uniformity, complete range of pore sizes
(3)Flexible and modular for easy linear scaling
(4)Low shear force, especially suitable for sensitive protein products and virus processing
(5)Compatible with mainstream R&D industrial hollow fiber TFF systems
Flat Cassettes
Flat cassettes are cutting-edge filtration devices designed to provide precise and efficient separation of particles and microorganisms from liquids. Flat cassettes employ advanced membrane technology, making them ideal for a wide range of applications in industries such as biotechnology, pharmaceuticals, food and beverage, and water treatment.
Features
(1)Quick and easy installation
(2)Thorough and convenient cleaning
(3)Low working volume
(4)High efficiency retention and large flux
Hollow Fiber and Flat Cassettes
Compared to hollow fiber, the microfiltration membrane of flat cassettes has significant limitations in clarifying and filtering samples with high solid content and high viscosity, as they are prone to channel clogging. Their mesh channel structure is more suitable for the concentration of low-viscosity and low-concentration samples without solid particles, such as buffer exchange and concentration between chromatographic columns.
