What Is The Principle Of Tangential Flow Filtration?

Tangential flow filtration refers to the filtration form in which the liquid flow direction is perpendicular to the filtration direction. The traditional liquid dead angle filtration is most microporous filtration (MF, microfiltration), including the filtration form used for sterilization filtration. The flow direction of liquid is the same as that of filtration. With the filtration process, the thickness of cake layer or gel layer on the membrane surface gradually increased and the flow rate decreased gradually. When the filter medium is ultrafiltration membrane or microfiltration membrane with small pore size, the solid content in the feed liquid is high. The dead end filtration method is adopted, and the flow rate decreases rapidly. Therefore, dead corner filtration can only handle a small amount of feed liquid. For large-scale liquid-liquid filtration, tangential flow filtration is required. Liquid flow will produce shear forces on the surface of the filter media, thereby reducing the accumulation of cake layer or gel layer and ensuring stable filtration rate. Therefore, tangential flow filtration is widely used in ultrafiltration (UF) and partial microfiltration (MF) processes.