Verification summary of service life of ultrafiltration membrane package

First of all, according to the actual experiment or production task, we expect the longest use time and maximum number of times of the film bag, and this number is our expectation for the number of times of use of the film bag. Then define process parameters, cleaning methods, storage methods, and verify monitoring parameters. The validation scheme is formulated according to these parameter methods. You can choose smaller film packaging, such as 0.1 square meters. The film packaging and the film packaging used in actual production must be produced by the same manufacturer and made of the same materials and processes. Then simulate the actual production process, in cleaning, before use, after use, cleaning, storage, before use cleaning, after use, after use cleaning Save cycle for verification. The integrity, water flux, sediment analysis, sample yield and quality analysis of membrane packaging shall be tested every certain number of times. Determine the number of times to use film packaging according to the verification results.

After determining the number of times, it is necessary to monitor the water flux, integrity, process parameters, product quality, cleaning and flushing water, etc. in the actual production process. Generally, the water flux is not less than 80% of the initial water flux. The integrity test method usually uses diffusion flow. For specific standards, please refer to the manufacturer's standards. During ultrafiltration, process parameters (such as TMP, flux and yield) will be monitored, and polymers, impurities and precipitates will be analyzed and evaluated. The TOC, conductivity, endotoxin and microbial limit of the final eluent were tested. In case of nonconformity, conduct corresponding deviation analysis and determine whether the film packaging needs to be replaced after evaluation.