20nm Virus Filter
Nowadays, 20nm virus filter is widely used. 20nm virus filter employs a size exclusion mechanism to achieve virus clearance. The operating principle is based on viruses being larger than the membrane pore size, allowing the product to pass through while the viruses are retained. Leveraging the virus size-based clearance mechanism, the 20nm virus filter not only enables efficient clearance of small viruses but also effectively eliminates virus particles of various types, including the mouse leukemia virus with a diameter of 80-100nm. What’s more, our 20nm virus filter utilizes PES membrane with a uniform pore size distribution, ensuring robust retention capability for small viruses.
Product Introduction
20nm Virus Filter
Description
Protein recovery and log virus removal
|
|
Thrombin |
Monoclonal antibodies |
Polyclonal antibodies |
Albumin |
|
20nm |
98% |
98% |
98% |
98% |
|
Parvovirus LRV |
>5 |
>5 |
>5 |
>5 |
LRV: virus removal log
Robust Quality Assurance System
Guidling 20nm virus filters are backed by a comprehensive quality assurance system, ensuring high throughput, high capacity and efficient retention of small viruses. Each product undergoes independent testing to ensure the integrity of the membrane components. We guarantee that every unit delivered to you is ready for reliable use, providing peace of mind without any concerns.
Experiment
The result of using nanofiltration (pore size 20 nm) to remove porcine parvovirus (PPV) from intermediate human immunoglobulin product
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|
20111201S |
20111202S |
20111203S |
|||
|
filtration Volume/L·m-2 |
residual titer decreased titer LgTCID50/0.1mL |
residual titer decreased titer LgTCID50/0.1mL |
residual titer decreased titer LgTCID50/0.1mL |
|||
|
0 |
5.38 |
|
5.07 |
|
5.44 |
|
|
5 |
0.50 |
4.88 |
0.88 |
4.19 |
0.57 |
4.87 |
|
15 |
1.19 |
4.19 |
2.07 |
3.00 |
1.75 |
3.69 |
|
25 |
1.82 |
3.56 |
2.07 |
3.00 |
2.25 |
3.19 |
|
35 |
1.82 |
3.56 |
2.25 |
2.82 |
2.70 |
2.74 |
|
45 |
1.51 |
3.87 |
2.44 |
2.63 |
2.32 |
3.12 |
|
50 |
1.69 |
3.69 |
2.19 |
2.88 |
2.19 |
3.25 |
|
55 |
1.25 |
4.13 |
2.50 |
2.57 |
2.44 |
3.00 |
|
60 |
1.26 |
4.12 |
1.63 |
3.44 |
1.88 |
3.56 |
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