TFF Filter Holder

Cassettes holder

Choosing a Cassette Holder

Designed for optimum performance and product recovery, Guidling TFF cassette holders are available in a variety of sizes to meet every application requirement. This way, applications that are developed on a small system using a cassette can be easily scaled up, either by adding additional cassettes to the holder or by scaling into a larger cassette format and holder configuration with an identical flow path .

Holder Sizes

TFF cassette holders for the medium and large-scale production environment have a small footprint yet still are capable of holding large areas of the membrane. All stainless steel cassette holders are engineered to precise specifications with a high standard internal and external surface finish and are available with either manual torque (MT) or auto torque (AT) compression systems for ease of use. Operators must use calibrated torque wrenches (supplied with the holder) to effect the required compression of cassettes and gaskets in a manual torque filter cassette holder.

Auto-torque Feature

Auto-torque cassette holders automatically compensate for cassette compression and temperature reduction. They also eliminate variability in technique between operators. Auto-torque filter cassette holders are recommended for process-scale validated processes.
Sanitary stainless steel holders may be sterilized by steam or autoclaving without cassettes installed.

Fittings Kits

Complete fittings kits consisting of pressure gauges, valves, filtrate manifold, connectors, gaskets, and clamps are available for most cassette holders. Ordering a complete fitting kit with the cassette holder simplifies installation into a system. It avoids potential delays in starting your process due to missing parts.

Description
The TFF filter holder is optimized for the use with up to five small Crossflow cassettes (0.1–0.5 m²). The filter holder can be thermally sterilized by autoclaving or inline steaming if the pressure compensation tools are used. Typical applications for the Small covers the whole range of pharmaceutical and biotechnological crossflow applications like concentration and diafiltration of proteins, vaccines, viruses, antibodies, oligo nucleotides, endotoxin removal etc. The system is suitable for cell harvesting and clarification processes.

The Small Filter holder features the latest advances in crossflow design:
– vertical orientation
– self draining system
– low minimal hold-up volume
– large retentate channels
– cGMP construction and operation
It is designed for low to medium volume applications from 1–100 L.

Technical specifications

Application:
– process development
– pre-clinical trials
– scaling studies
– pilot scale and small volume production
– in-process volume reduction
– desalting protein solutions
– purification and recovery of antibodies or recombinant proteins
– preparation of samples (concentrating, desalting) before or after column chromatography

Ordering Information

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