Application Fields Of Tangential Flow Filtration Technology

Tangential flow filtration technology is a membrane separation technology widely used at present. It belongs to molecular weight filtration, and the molecular weight range is usually 1-100000 KD; In tangential flow, the liquid passes through the membrane surface. The liquid pressure is filtered through the membrane. The trapped part circulate back and forth in the system. The liquid flows through the membrane surface at a certain rate throughout the whole process. The surface of the filter is also washed, so that the gel layer will not form on the surface of the membrane, so that the particles in the liquid will not quickly clog up the filter membrane and maintain a stable filtration rate. Ultrafiltration is a method to separate tiny particles and soluble molecules in solution; This separation is mainly based on the size of molecules, but the permeability of membrane medium will also be affected by the chemistry, shape, molecular and charge characteristics of samples; Ultrafiltration can only separate molecules with a size difference of more than 3-5 times, which is not suitable for separating molecules with similar sizes.

Application fields of tangential flow filtration technology

▼ separation and purification of blood products

▼ concentration and washing of vaccines and coupling products

▼ single pyrogen removal, such as pyrogen removal of traditional Chinese medicine injection

▼ concentration, purification and separation of proteins, polypeptides, polysaccharides, viruses and antibodies

▼ separation of cells / cell debris (cell collection, cell removal)

▼ replacement of buffer, such as the change of buffer system before and after chromatography